Recent Progress in Cancer Research 2007

Rok: 2007
ISBN: 9788178952536
OKCZID: 110869251

Anotace

Cellular signaling pathways are fundamental to normal cell processes such as cell cycle progression, growth, differentiation, and death. A delicate balance between activation and inhibitory signals must be maintained such that the normal cellular integrity is not altered. Cancer arises from a stepwise accumulation of genetic changes that liberate neoplastic cells from the homeostatic mechanisms which normally govern cell proliferation. Extensive evidence indicates that human cancers exhibit genetic alterations in multiple tumor suppressor genes and oncogenes. Signaling via proto-oncogenes has been associated with the malignant transformation, growth, and progression of many solid human tumors. The interaction of growth factors, cytokines, and hormones with specific membrane receptors triggers a cascade of intracellular biochemical signals, resulting in the activation and repression of various subsets of genes. The current goal in cancer therapy is to use our knowledge of the molecular alterations in a cancer cell to choose the most appropriate signal transduction inhibitor for an individual patient. Improvement in our understanding of the intrinsic aberrances found in cancer cells will enable the design of novel cancer treatments which specifically target these changes. Understanding the molecular events that occur during the multistep process of carcinogenesis will provide the imperative information necessary for battling this devastating disease. The review articles presented in this book cover a wide range of scientific topics related to the molecular mechanism of human cancer.

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